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A group of transhumans called the Supreme begin conquering neighboring worlds to forcibly elevate the inhabitants to their superior form. Stronger, faster, and above all, smarter than most Primes their neighbors cannot resist them, militarily or philosophically. The Mandate moves to intervene, but their local response is slow. Before the end of the year, the Mandate and the Supreme is engaged in a full-scale war that the Mandate is losing. By 2385 a fifth of the rim is under the control of the Supreme, and they have started entering the core worlds.
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